This list I probably won't finish this year, or maybe even in my lifetime!  Currently I've only completed 10 of them and a good amount of them will cost me a week's worth of groceries.
The 2010 Big Eat List
 1. Roast chicken and bread salad at Zuni
 2. Coffee-rubbed pork shoulder at Range
 3. Carnitas taco at La Taqueria
  4. Fried chicken and waffles at Little Skillet
  5.   Chasu ramen at Katana-Ya
 6. Basil gimlet at Rye
 7. Crab with cellophane noodles at the Slanted Door
  8. Morning bun at Tartine Bakery
 9. Tofu soup with kimchi at My Tofu House
 10. Nick’s Baja-style fish tacos at The Taco Shop at Underdogs
 11. Pork sugo with pappardelle at Delfina
 12. Porchetta sandwich at RoliRoti
 13. Soup dumplings at Shanghai Dumpling King
 14. Beef brisket sandwich at Il Cane Rosso
 15. Any seasonal flavor at Scream Sorbet
 16. Katsu curry from Muracci’s Japanese Curry & Grill
 17. Samusa soup at Burma Superstar
18. Oysters on the half shell at Swan Oyster Depot
  19. Lobster pot pie at Michael Mina
 20. Salumi misti plate at Perbacco
 21. Pizza margherita at Pizzeria Delfina
 22. Vietnamese roasted pork sandwich at Saigon Sandwich
 23. Beer sausage with sauerkraut and grilled onions at Rosamunde Sausage Grill
(Bonus: Bring it Toronado next door and grab a beer to go with it.)
 24. Blue Bell Bitter from the cask at Magnolia Pub
 25. Loaf of bread straight out of the oven at Tartine
 26. A bottle of Burgundy at RN74
 27. Papaya salad with salty crab at Sai Jai Thai
 28. A Gibraltar at Blue Bottle Café
 29. Tuna tartare and a gin martini at Bix
 30. Burger at Fish & Farm
 31. Tuna Tostada at Tacolicious
 32. Pupusas at Balompie Café
 33. Prime rib at House of Prime Rib
 34. Way too much cold sake at Oyaji
 35. Salted-caramel ice cream at Bi-Rite Creamery
 36. Dry-fried chicken wings at San Tung
 37. Rotisserie chicken at Limón Rotisserie
 38. Burger and fries at the bar at Spruce
 39. Pierna enchilada torta at La Torta Gorda
 40. Cheeseburger with sweet potato fries at Taylor’s Automatic Refresher
 41. Pho ga at Turtle Tower
  42. Fried-shrimp po’boy at Brenda’s French Soul Food
 43. An Old Fashioned at Alembic
 44. One of Neyah White’s shrubs at Nopa
 45. Secret Breakfast from Humphry Slocombe
 46. Chips and salsa at Papalote
 47. Ceviche and a pisco sour on the patio at La Mar Cebichería Peruana
  
48. Angels on horseback at Anchor & Hope49. Ginger snaps at Miette 
 50. An obscure Belgian beer at The Monk’s Kettle
 51. Maccaronara with ricotta salata at A16
  52. Coconut buns from King’s Bakery
 53. Carnitas at Nopalito
 54. Spiced-chocolate doughnut at Dynamo Donut with a Four Barrel coffee
 55. Chicken porridge for breakfast at the Bush Street Out the Door
 56. Nuestra Paloma at Beretta
 57. Agnolotti at Quince
 58. Chicharrones from 4505 Meats
 59. Huarache with cactus salad at El Huarache Loco
(Saturdays at the Alemany Farmers Market)
 60. The Little Star at Little Star Pizza
 61. Egg custard tart at Golden Gate Bakery
 62. Dim sum at Ton Kiang
 63. Meatballs with grapes at Aziza
 64. Sand dabs at Tadich Grill
 65. Cookies-and-cream cookie and milk at Anthony’s Cookies
 66. Pig parts at Incanto
 67. Paper masala dosa at Dosa
 68. The housemade hot dog at Absinthe
 69. Foccacia at Liguria Bakery
 70. Omakase menu at Sebo
  
71. Scotch egg at Wexler’s72. Shanghai Buck at Heaven’s Dog
  73. Popovers with strawberry butter at the Rotunda
 74. Corned-beef sandwich with Gruyère at The Sentinel
 75. Fried green beans at Coco500
 76. Chicken hash at Ella’s
 77. Eggs benedict on the back patio at Zazie
 78. Super burrito at Taqueira Cancun
 79. Onion strings at Alfred’s Steakhouse
 80. Apple fritter at Bob’s Donuts
 81. Chicken curry lunch special at Punjab Kabab House
 82. Fried chickpeas at Piqueo’s
 83. French fries at Universal Cafe 
 84. A margarita at Tommy’s Mexican Restaurant
  85. Pulled-pork sandwich at Roadside BBQ
 86. A cheese slice at Arinell Pizza
 87. Sesame balls at Yank Sing
 88. Buckwheat crepe and a French cider at Ti Couz
 89. Lettuce cups at Betelnut
 90. Korean taco at Namu’s market stand
 91. Albondigas soup at Mijita
 92. Bacon-wrapped hot dog from a cart in the Mission
(preferably when you’re drunk)
 93. Seven courses of beef at Pagolac
 94. The house cappuccino at Tosca Café
 95. 3 a.m. bowl of caldo verde soup at Grubstake
 96. Ube ice cream from Mitchell’s
 97. Lamb schawerma at Truly Mediterranean
 98. Bloody Mary with brunch at Foreign Cinema
 99. Clam chowder at Hog Island Oyster Co.
(ok, get some oysters too)
  100. Menage a Trois at Ike’s Place
I've got a long way to go, but I think I can at least get 50% by the end of the year.  We'll see!